Head of the Physiology Research Center

Dr. Ali Ghanbari

Telephone: 023- 33654186





The Physiology Research Center was approved in principle in 2004 and gained the final approval of the relevant ministry in 2007.

Address of the center in the scientometric system of the Ministry of Health:



The research fields of Semnan Physiology Research Center have been mainly in the field of neuroscience. These include neurophysiology, neuropharmacology, neuroanatomy, molecular neurobiology, learning and memory neurobiology (behavioral and electrophysiology), cerebrovascular function in animal models, hemodynamic changes in animal models, neuromuscular conduction, wound healing, and neuroscience including neuroscience neuropathology. Recently, new research has been conducted on diabetes, the study of new antidiabetic drugs, and the complications of diabetes, especially diabetic nephropathy.

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Research Priorities

Neurophysiology, neuropharmacology, neuroanatomy, molecular neurobiology, learning and memory neurobiology (behavioral and electrophysiology), ‌ function of cerebral arteries in animal models, changes in blood pressure, neuromuscular conduction, wound healing, clinical sciences including neuropsychology and neuropathology.

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Features and capabilities

Electrophysiological laboratories for recording LTP and recording single cell activity, measuring nerve and muscle conduction velocity, learning and behavioral memory including passive avoidance learning, conditional fear, Spatial learning and memory (Morris water maze) and measurement of motor activity, behavioral evaluation of pain (neuropathy and acute and chronic pain), behavioral evaluation of addiction, anxiety and sleep, evaluation of stroke (ischemia, edema and vascular permeability) in laboratory animals, evaluation of vascular activity (changes in blood pressure), evaluation of brain trauma, microdialysis, evaluation and measurement of proteins and enzymes, behavioral evaluation of stress and depression, evaluation of wound healing and stretching in laboratory animals, evaluation of the effects of exercise on physiological processes, electrophysiology of kindling.


  • Impact of different intensities of forced exercise on deficits of spatial and aversive memory, anxiety-like behavior, and hippocampal BDNF during morphine abstinence period in male rats 
  • MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress 
  • Neuromodulatory effects of anti-diabetes medications: A mechanistic review 
  • Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus 
  • Effect of crocin on morphine tolerance and serum BDNF levels in a rat model of neuropathic pain 
  • Antidepressant-like and memory-enhancing effects of the N-type calcium channel blocker ziconotide in rats 
  • Chronic treatment with apelin, losartan and their combination reduces myocardial infarct size and improves cardiac mechanical function 
  • Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review 
  • Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes 
  • The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review
  • Protective effects of curcumin and its nano-phytosome on carrageenan-induced inflammation in mice model: Behavioral and biochemical responses
  • PPAR-a agonist fenofibrate ameliorates oxidative stress in testicular tissue of diabetic rats 
  • Effects of levothyroxine on learning and memory deficits in a rat model of Alzheimer's disease: the role of BDNF and oxidative stress
  • Adult weight gain and the risk of cardiovascular disease: a systematic review and dose-response meta-analysis of prospective cohort studies 
  • Therapeutic effects of spirulina platensis against adolescent stress-induced oxidative stress, brain-derived neurotrophic factor alterations and morphological remodeling in the amygdala of adult female rats 


Physiology Research Center

Semnan University of Medical Sciences and Health Services,

Faculty of Medicine, Damghan road, Semnan, Iran

Telefax: 0098 23 33654207